Functionality and quality of life in obsessive-compulsive disorder with schizophrenia

Abstract

The aim of this study was to determine the relationship between symptoms of obsessive-compulsive disorder comorbid with schizophrenia, and quality of life and functioning. Materials and methods: The study was designed on 3 groups of patients, each group consisting of 17 patients who were admitted to Ondokuz Mayis University Psychiatry Clinic. The first group consisted of schizophrenia patients with comorbid obsessive-compulsive disorder. The second group includes patients with schizophrenia only, whereas patients with a diagnosis of obsessive compulsive disorder (OCD) only formed the third group. The second and third group were age, illness duration and gender matched with the first one. The patients were evaluated with, sociodemographic data form, Positive and Negative Syndrome Scale (PANSS), Yale-Brown Obsessive Compulsive Scale (YBOCS), Global Assessment of Functioning (GAF), World Health Organization Quality of Life Brief form (WHOQOL). Results: Schizophrenia patients with OCD and schizophrenia-only patients presented with lower scale scores as to WHOQOL social relationships domain subscale and GAF points than OCD-only patients. Functionality was negatively correlated with PANSS positive, general psychopathology and total scores in schizophrenia-only and schizophrenia-OCD groups. WHOQOL social relationships domain sub-scale was negatively correlated with YBOCS in schizophrenia-OCD group. Moreover, functionality and WHOQOL physical, psychological domain subscales was negatively correlated with YBOCS scores in OCD-only patients. Conclusion: Functionality and social relationships domains in schizophrenia-OCD patients showed similar patterns with schizophrenia-only patients. Severity of psychotic symptoms was correlated with functionality but not with total quality of life scores in oschizophrenia-OCD patients. Beside, severity of obsessive compulsive symptoms was related with social relationships domain of life quality in schizophrenia-OCD group patients.