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Morphometric and histopathologic evaluation of the effects of cloprostenol and equine chorionic gonadotropin administration on the reproductive organs of female rats

Date

2019

Author

Gurler, Hande
Demirel, Murside Ayse
Karaca, Efe
Acar, Duygu Baki
Akcay, Aytac
Gulbahar, Mustafa Yavuz

Metadata

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Abstract

The aim of this study was to determine the short-, mid- and long-term effects of cloprostenol (a synthetic analogue of prostoglandin F2 alpha, PG) and equine chorionic gonadotropin (E) administration on reproductive organs (uterine tissue and ovaries) in female rats. Three different groups, PG, E, and control (C), were created, as well as six subgroups of the PG and E groups. After the treatment procedure, reproductive organs were removed surgically 7, 14, and 21 days after the last injection. Morphometric and histopathological changes in tissues were evaluated. It was shown that PG and E had a moderate proliferative effect on epithelial cells and endometrial glands, especially in the mid-term. It was also observed that, regardless of the time of application, some pathological changes can result from hormone administration.

Source

Medycyna Weterynaryjna-Veterinary Medicine-Science and Practice

Volume

75

Issue

3

URI

https://doi.org/10.21521/mw.6195
https://hdl.handle.net/20.500.12712/10958

Collections

  • Scopus İndeksli Yayınlar Koleksiyonu [14046]
  • WoS İndeksli Yayınlar Koleksiyonu [12971]



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