PubMed İndeksli Yayınlar KoleksiyonuPubMed Indexed Publications Collectionhttps://hdl.handle.net/20.500.12712/72024-03-28T18:08:42Z2024-03-28T18:08:42ZInvestigation of the correlation between mood disorder symptoms and disease activity and functional status in rheumatoid arthritis patientsDuran, Tuğba İzciUlusoy, HasanPamukçu, MelihAltınbaş, Kürşathttps://hdl.handle.net/20.500.12712/334292022-09-02T17:43:07Z2021-01-01T00:00:00ZInvestigation of the correlation between mood disorder symptoms and disease activity and functional status in rheumatoid arthritis patients
Duran, Tuğba İzci; Ulusoy, Hasan; Pamukçu, Melih; Altınbaş, Kürşat
To investigate the correlation between depressive-anxiety symptoms, mixed features, disease activity, and functional status in patients with rheumatoid arthritis (RA) in the light of the shared underlying etiology in both disorders. Materials and methods: The study included 556 patients with RA. RA disease activity was measured using the Disease Activity Score 28-joint count C reactive protein (DAS28-CRP), and the patients were evaluated by a Health Assessment Questionnaire (HAQ). The Hospital Anxiety and Depression Scale (HADS), Mood Disorder Questionnaire (MDQ), and Modified Hypomania Checklist (mHCL) were used to evaluate the mixed depression and bipolarity status of the patients. Results: Of the patients, 430 (77.3%) were female and 126 (22.7%) were male. The median age was 57 years, the median HAQ score was 0.55 points, and the median DAS28-CRP score was 4.1 points. The evaluation of the patients by DAS28-CRP revealed that 58.5% of the patients had moderate and severe disease activity, while only 23.4% of them were in remission. The group using the combination of synthetic disease-modifying anti-rheumatic drugs (sDMARD) and steroid therapy had significantly higher HAD-depression, HADanxiety, mHCL, DAS28-CRP, HAQ, and MDQ scores than the group using sDMARD alone. The grouping of the patients based on the DAS28-CRP cut-off scores showed that the patients with moderate and severe disease activity had significantly higher HADS, mHCL, MDQ scores than those in remission and those with mild disease activity (p < 0.001). Conclusion: Disease severity and functional status in RA can be affected by comorbid anxiety-depressive and mixed symptoms. Therefore, clinicians should consider screening the depressive-anxiety and mixed mood symptoms of RA patients. Moreover, patients who use steroid therapy are more susceptible to mood symptoms (anxiety, depression, bipolarity), which should also be considered during the follow-up of patients
Tam Metin / Full Text; Q3; SCI-Expanded; WOS:000731456300025
2021-01-01T00:00:00ZThe inhibition of Src kinase suppresses the production of matrix metalloproteinases in from synovial fibroblasts and inhibits MAPK and STATs pathwaysYalçın Kehribar, DemetÖzgen, MetinYolbaş, ServetYıldırım, AhmetBaşak Türkmen, NeşeÖnalan Etem, EbruÇiftçi, OsmanÖzercan, İbrahim HanifiKoca, Süleyman Serdarhttps://hdl.handle.net/20.500.12712/333642022-08-24T12:58:51Z2021-01-01T00:00:00ZThe inhibition of Src kinase suppresses the production of matrix metalloproteinases in from synovial fibroblasts and inhibits MAPK and STATs pathways
Yalçın Kehribar, Demet; Özgen, Metin; Yolbaş, Servet; Yıldırım, Ahmet; Başak Türkmen, Neşe; Önalan Etem, Ebru; Çiftçi, Osman; Özercan, İbrahim Hanifi; Koca, Süleyman Serdar
Background/aim: The purpose of this study was to investigate the antiarthritic potentials of the inhibition of Src kinase in vivo and in vitro settings. Materials and methods: Arthritis was induced by intradermal injection of chicken type II collagen combined with incomplete Freund’s adjuvant (collagen induced arthritis [CIA] model) in Wistar albino rats. One day after the onset of arthritis, dasatinib, a potent Src kinase inhibitor, (5 mg/kg/day) was given via oral gavage. Tissue Src, Fyn, MAPK and STAT mRNA expressions were determined by real-time polymerase chain reaction. On the other hand, fibroblast like synoviocytes (FLSs) were harvested patients with rheumatoid arthritis (RA) undergoing surgical knee joint replacement. FLSs were stimulated with cytokines and dasatinib was added in different concentrations. MMP –1, –3, and –13 levels in FLSs culture were determined by ELISA. Results: The tissue mRNA expressions of Src, Fyn, MAPK and STATs were increased in the arthritis CIA group compared to the control group. Their mRNA expressions in the CIA + dasatinib group were decreased and similar in the control group. In in vitro setting, MMP –1, –3, and –13 expressions from FLSs induced by IL-1β and TNF-α were increased, while dasatinib suppressed their productions from FLSs. Conclusion: The present study shows that the inhibition of Src kinase has antiarthritic potentials in both in vivo and in vitro settings. Src kinase inhibition may be candidate to further research in human RA.Key words: Rheumatoid arthritis, collagen induced arthritis, src kinase, matrix metalloproteinase.
WOS:000691664800007; SCI; PubMed ID33714238; Q3
2021-01-01T00:00:00ZThe effect of breast size and density in Turkish women on radiation dose in full-field digital mammographyİdil Soylu, AyşegülÖztürk, MesutSoylu, Ahmet Veyselhttps://hdl.handle.net/20.500.12712/333632022-08-24T12:20:41Z2021-01-01T00:00:00ZThe effect of breast size and density in Turkish women on radiation dose in full-field digital mammography
İdil Soylu, Ayşegül; Öztürk, Mesut; Soylu, Ahmet Veysel
Objective: The purpose of this study was to look into the relationship between breast size and mammographic breast density in women and breast radiation dose on full-field digital mammography (FFDM), as well as the factors that influence radiation dose. Materials and Methods: The study included a total of 2,060 FFDM images from 515 consecutive participants. The participants were divided into two groups: those exposed to high doses (>3 mGy) and those exposed to low doses (<3 mGy). Moreover, the researchers analyzed the relationship between mean glandular dose (MGD) of the breast and patient age, compressed breast thickness, compression force, mammographic breast composition, and mammographic breast size. Results: The mean mammographic breast volume was 936.2 ± 425.2 (114.5–3,018) mL, and the mean compressed breast tissue thickness was 56.75 ± 10.44 mm. Moreover, the mean MGD in the high-dose group was 3.51 ± 0.48 mGy and 1.92 ± 0.56 mGy in the low-dose group. The high-dose group had greater breast thickness, diameters, volume, compression pressure, and surgical rate. However, the high-dose group was younger and had less dense breasts. In multivariate logistic regression analysis, the most important predictors of dose determination were breast thickness [odds ratio (OR): 1.178, 95% confidence interval (CI): 1.156–1.200, p<0.001], history of previous surgery (OR: 2.210, 95% CI: 1.417–3.447, p<0.001), compression force (OR: 1.008, 95% CI: 1.004–1.013, p<0.001), and breast density (OR: 1.873, 95% CI: 1.359–2.580, p<0.001). Conclusion: Women with larger breast volumes are subjected to higher doses of radiation. Therefore, breast-screening programs can be individualized to young women with larger breast volumes and women who have had breast-conserving surgery.
WOS:000704610500004; ESCI; PubMed ID34651109
2021-01-01T00:00:00ZPredictors of full functional recovery in endovascularly treated patients with aneurysmal subarachnoid hemorrhageUzunkaya, FatihSoylu, Ayşegül İdilhttps://hdl.handle.net/20.500.12712/333592022-08-24T12:53:18Z2021-01-01T00:00:00ZPredictors of full functional recovery in endovascularly treated patients with aneurysmal subarachnoid hemorrhage
Uzunkaya, Fatih; Soylu, Ayşegül İdil
Background/aim: The knowledge of factors influencing functional outcomes after aneurysmal subarachnoid hemorrhage (ASH) has significantly increased in recent decades, still not enough. We aimed to identify the predictors of full functional recovery (FFR) in endovascularly treated patients with ASH. Materials and methods: A retrospective review was performed of adult patients who underwent endovascular treatment for ASH in a 5-year period. The association was evaluated of variables with FFR, defined as a modified Rankin Scale score of 0 or 1 at a 3-month follow-up. Results: This study included 204 patients with a percentage of FFR of 62.7%. On univariate analysis, the following variables were associated with FFR: younger age, male sex, no history of hypertension, posterior circulation aneurysm, better modified-Fisher grade (mFG), better Hunt-Hess grade, better Glasgow Coma score, lower platelet-to-lymphocyte ratio (PLR), lower neutrophil-to-lymphocyte ratio (NLR), and higher platelet-to-neutrophil ratio (PNR). On multivariate analysis, younger age (OR = 0.95, 95% Cl = 0.92–0.98, p = 0.003), better mFG (OR = 0.66, 95% Cl = 0.48–0.97, p = 0.03), lower PLR (OR = 0.993, 95% Cl = 0.990–0.997, p = 0.001), lower NLR (OR = 0.89, 95% Cl = 0.83–0.95, p = 0.01) and higher PNR (OR = 1.08, 95% Cl = 1.01–1.10, p = 0.01) showed the strongest association with FFR. Conclusion: With the administration of endovascular treatment, most of the patients with ASH can return to a normal productive life. Younger age, better mFG, lower PLR and NLR, as well as higher PNR, increase the likelihood of FFR.Key words: Subarachnoid hemorrhage, cerebral aneurysm, outcome, prediction
WOS:000691544700052; PubMed ID34174801; SCI; Q3
2021-01-01T00:00:00Z