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Investigation of arenesulfonyl-2-imidazolidinones as potent carbonic anhydrase inhibitors
(Taylor & Francis Ltd, 2015)
A series of arenesulfonyl-2-imidazolidinones incorporating methyl, isopropyl, methoxy, halogen and phenyl moieties were prepared and tested as possible inhibitors of two members of the pH regulatory enzyme family, carbonic ...
Kinetic and in silico analysis of thiazolidin-based inhibitors of alpha-carbonic anhydrase isoenzymes
(Taylor & Francis Ltd, 2013)
Carbonic anhydrases (CAs, EC 4.2.1.1) are inhibited by sulfonamides, inorganic anions, phenols, salicylic acid derivatives (acting as drug or prodrugs). A novel class of CA inhibitors (CAIs), interacting with the CA isozymes ...
Inhibition of human carbonic anhydrase isozymes I, II and VI with a series of bisphenol, methoxy and bromophenol compounds
(Taylor & Francis Ltd, 2012)
Carbonic anhydrase inhibitors (CAI) are valuable molecules as they have several therapeutic applications, including anti-glaucoma activity. In this study, inhibition of three human carbonic anhydrase (hCA, EC 4.2.1.1) ...
Carbonic anhydrase inhibitory properties of some uracil derivatives
(Taylor & Francis Ltd, 2017)
Inhibitors of carbonic anhydrase (CA) have been carried out in many therapeutic applications, especially antiglaucoma activity. In this study, we investigated some uracil derivatives (4-12) to inhibit human CA I (hCA I) ...
Comparison of blood carbonic anhydrase activity of athletes performing interval and continuous running exercise at high altitude
(Taylor & Francis Ltd, 2019)
The effects of high-intensity interval and continuous exercise on erythrocytes carbonic anhydrase (CA, EC 4.2.1.1) activity levels were scarcely investigated up until now. Here we present a study focused on the CA activity ...
Influence of Different Dietary Lipids on the Activity of Metabolic Enzymes in Brown Trout (Salmo trutta)
(Central Fisheries Research Inst, 2014)
The objective of this experiment was to test the effect of different dietary lipids in brown trout feeding on the activity of metabolic enzymes, such as hexokinase (HK), glucose-6-phosphate dehydrogenase (G6PD) and ...
Interaction of carbonic anhydrase isozymes I, II, and IX with some pyridine and phenol hydrazinecarbothioamide derivatives
(Pergamon-Elsevier Science Ltd, 2015)
A series of hydrazinecarbothioamide derivatives incorporating ethyl, phenyl, tolyl, benzyl, and allyl moieties were prepared and tested as possible inhibitors of three members of the pH regulatory enzyme family, carbonic ...
Synthesis and carbonic anhydrase inhibitory properties of novel uracil derivatives
(Pergamon-Elsevier Science Ltd, 2015)
Carbonic anhydrase (CA) inhibitors are valuable molecules based on several therapeutic applications, including antiglaucoma activity. In the present study, inhibition of two human cytosolic carbonic anhydrase isozymes I ...
Carbonic anhydrase inhibitors: Design, synthesis, kinetic, docking and molecular dynamics analysis of novel glycine and phenylalanine sulfonamide derivatives
(Pergamon-Elsevier Science Ltd, 2015)
The inhibition of two human cytosolic carbonic anhydrase isozymes I and II, with some novel glycine and phenylalanine sulfonamide derivatives were investigated. Newly synthesized compounds G1-4 and P1-4 showed effective ...
Purification and characterization of carbonic anhydrase from sheep kidney and effects of sulfonamides on enzyme activity
(Pergamon-Elsevier Science Ltd, 2013)
Carbonic anhydrase (CA, EC: 4.2.1.1) was purified from sheep kidney by affinity chromatography on a Sepharose 4B-tyrosine-sulfanilamide column. By means of two consecutive procedures, the enzyme (sCA) was purified 227.61-fold ...
