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alpha-Carbonic anhydrases are sulfatases with cyclic diol monosulfate esters
(Taylor & Francis Ltd, 2012)
Carbonic anhydrases (CA) catalyze activated ester hydrolysis in addition to the hydration of CO 2 to bicarbonate. They also show phosphatase activity with 4-nitrophenyl phosphate as substrate but not sulfatase with the ...
Synthesis and carbonic anhydrase inhibitory properties of novel bromophenols including natural products
(Taylor & Francis Ltd, 2012)
(2-Bromo-3,4-dimethoxyphenyl) (3,4-dimethoxyphenyl) methanone (10) and its derivatives with Br, one dibromide and isomeric three tribromides, were synthesized. Demethylation of these compounds afforded a series of new ...
Inhibition of human carbonic anhydrase isozymes I, II and VI with a series of bisphenol, methoxy and bromophenol compounds
(Taylor & Francis Ltd, 2012)
Carbonic anhydrase inhibitors (CAI) are valuable molecules as they have several therapeutic applications, including anti-glaucoma activity. In this study, inhibition of three human carbonic anhydrase (hCA, EC 4.2.1.1) ...
Synthesis of novel mono and bis-indole conduritol derivatives and their alpha/beta-glycosidase inhibitory effects
(Pergamon-Elsevier Science Ltd, 2012)
Here we synthesized four novel indole conduritol derivatives 1-4 for the first time in the literature and probed their biological activities with the alpha and beta-glucosidases. The compounds showed quite effective ...
Carbonic anhydrase inhibitors: inhibition of human and bovine isoenzymes by benzenesulphonamides, cyclitols and phenolic compounds
(Taylor & Francis Ltd, 2012)
Carbonic anhydrase inhibitors (CAIs) are a class of pharmaceuticals used as anti-glaucoma agents, diuretics and anti-epileptics. We report here the inhibitory capacities of benzenesulphonamides, cyclitols and phenolic ...
Chromone containing sulfonamides as potent carbonic anhydrase inhibitors
(Taylor & Francis Ltd, 2012)
A series of sulfonamide derivatives incorporating substituted 3-formylchromone moieties were investigated for the inhibition of three human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms, hCA I, II, and VI. All these ...
Influence of pesticides on the pH regulatory enzyme, carbonic anhydrase, from European Seabass liver and bovine erythrocytes
(Elsevier Science Bv, 2012)
The objective of this study was to assess the inhibitory effects of six commonly used pesticides, cyhalothrin, cypermethrin, dichlorvos, methamidophos, chlorpyrifos and methylparathion, on the pH regulatory enzyme carbonic ...
Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b] indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2012)
Several 5,10-dihydroindeno[1,2-b]indole derivatives incorporating methoxy, hydroxyl, and halogen (F, Cl, and Br) moieties on the indene fragment of the molecule were prepared and tested against five carbonic anhydrase (CA, ...
Effects of dopaminergic compounds on carbonic anhydrase isozymes I, II, and VI
(Taylor & Francis Ltd, 2012)
Studies on carbonic anhydrase (CA, EC 4.2.1.1) inhibitors have increased due to several therapeutic applications while there are few investigations on activators. Here we investigated CA inhibitory and activatory capacities ...
