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Toplam kayıt 8, listelenen: 1-8
alpha-Carbonic anhydrases are sulfatases with cyclic diol monosulfate esters
(Taylor & Francis Ltd, 2012)
Carbonic anhydrases (CA) catalyze activated ester hydrolysis in addition to the hydration of CO 2 to bicarbonate. They also show phosphatase activity with 4-nitrophenyl phosphate as substrate but not sulfatase with the ...
Inhibition of acetylcholinesterase and butyrylcholinesterase with uracil derivatives: kinetic and computational studies
(Taylor & Francis Ltd, 2019)
Acetylcholinesterase (AChE) and Butyrylcholinesterase (BuChE) inhibitors are interesting compounds for different therapeutic applications, among which Alzheimer's disease. Here, we investigated the inhibition of these ...
Determination of the inhibitory effects of N-methylpyrrole derivatives on glutathione reductase enzyme
(Taylor & Francis Ltd, 2019)
Glutathione reductase (GR) is a crucial antioxidant enzyme which is responsible for the maintenance of antioxidant GSH molecule. Antimalarial effects of some chemical molecules are attributed to their inhibition of GR, ...
Biological Evaluation of Some Uracil Derivatives as Potent Glutathione Reductase Inhibitors
(Amer Inst Physics, 2016)
Discovery of glutathione reductase (GR) inhibitors has become very popular recently due to antimalarial and anticancer activities. In this study, GR inhibitory capacities of some uracil derivatives (UDCs) (1-4) were reported. ...
Synthesis and carbonic anhydrase inhibitory properties of novel uracil derivatives
(Pergamon-Elsevier Science Ltd, 2015)
Carbonic anhydrase (CA) inhibitors are valuable molecules based on several therapeutic applications, including antiglaucoma activity. In the present study, inhibition of two human cytosolic carbonic anhydrase isozymes I ...
Synthesis of 1,4-bis(indolin-1-ylmethyl)benzene derivatives and their structure-activity relationships for the interaction of human carbonic anhydrase isoforms I and II
(Pergamon-Elsevier Science Ltd, 2013)
Several 1,4-bis(indolin-1-ylmethyl)benzene-based compounds containing substituents such as five, six and seven cyclic derivatives on indeno part (9a-c) were prepared and tested against two members of the pH regulatory ...
Synthesis of novel mono and bis-indole conduritol derivatives and their alpha/beta-glycosidase inhibitory effects
(Pergamon-Elsevier Science Ltd, 2012)
Here we synthesized four novel indole conduritol derivatives 1-4 for the first time in the literature and probed their biological activities with the alpha and beta-glucosidases. The compounds showed quite effective ...
Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b] indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2012)
Several 5,10-dihydroindeno[1,2-b]indole derivatives incorporating methoxy, hydroxyl, and halogen (F, Cl, and Br) moieties on the indene fragment of the molecule were prepared and tested against five carbonic anhydrase (CA, ...