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Toplam kayıt 8, listelenen: 1-8
Inhibition of neuronal nitric oxide synthase prevents iron-induced cerebellar Purkinje cell loss in the rat
(Nencki Inst Experimental Biology, 2008)
Iron plays an important role in maintaining normal. brain function. However, in many neurodegenerative diseases abnormal iron accumulation in specific brain regions has been consistently reported. In this study, we ...
Iron-Induced Cerebellar Purkinje Cell Loss Is Ameliorated by Flunarizine
(Tubitak Scientific & Technical Research Council Turkey, 2009)
Aim: In this study, we investigated the effect of intracerebroventricular-injected iron neurotoxicity on the total number of cerebellar Purkiinje cells in rats and the possible neuroprotective effect of flunarizine, a ...
Neuroprotective effect of aminoguanidine on iron-induced neurotoxicity
(Pergamon-Elsevier Science Ltd, 2008)
Iron is a commonly used metal to induce neuronal hyperactivity and oxidative stress. Iron levels rise in the brain in some neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. A body of evidence indicates ...
Nitric oxide synthesis inhibition attenuates iron-induced neurotoxicity: A stereological study
(Elsevier Science Bv, 2008)
Iron overload and enhanced hydroxyl radical formation have been implicated as the causative factors of some neurodegenerative disorders. Therefore, iron is commonly used as a metal to induce neuronal hyperactivity and ...
Role of nitric oxide synthesis inhibitors in iron-induced nigral neurotoxicity: A mechanistic exploration
(Taylor & Francis Ltd, 2008)
In the central nervous system, nitric oxide (NO) has been suggested to be a cell-to-cell signaling molecule that regulates guanylyl cyclase, aconitase, and iron regulatory protein. NO is also one of the substances that is ...
Neuroprotection by 7-nitroindazole against iron-induced hippocampal neurotoxicity
(Springer/Plenum Publishers, 2007)
(1) Iron plays an important role in maintaining normal brain function. In some neurodegenerative disorders including Parkinson's and Alzheimer's disease, iron levels rise in the brain. It is known that higher iron levels ...
A calcium channel blocker flunarizine attenuates the neurotoxic effects of iron
(Springer, 2006)
Iron is a metal highly concentrated in liver and brain tissue, and known to induce neuronal hyperactivity and oxidative stress. It has been established that iron levels rise in the brain in some neurodegenerative diseases ...
The neurotoxic effect of iron on pyramidal cell number in rat hippocampus: A stereological study
(Wiley, 2003)
There have been numerous studies of neuronal hyperactivity and oxidative stress induced by iron. Moreover, it has been found that iron levels in the brain are markedly increased in some neurodegenerative diseases such as ...