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Toplam kayıt 9, listelenen: 1-9
Blocking of L-type calcium channels protects hippocampal and nigral neurons against iron neurotoxicity the role of L-type calcium channels in iron-induced neurotoxicity
(Informa Healthcare, 2013)
Iron plays an important role in maintaining normal brain function. However, iron overload and enhanced hydroxyl radical formation have been implicated as the causative factors of some neurodegenerative disorders such as ...
Seizures with Pentylenetetrazoll indling Cause a Decrease in the Number of Pyramidal Neurons in the Rat Hippocampus
(Sci Printers & Publ Inc, 2016)
OBJECTIVE: To investigate the effects of pentylenetetra-zole (PTZ) kindling on the number of pyramidal neurons in the rat hippocampus. STUDY DESIGN: Using unbiased stereology, we calculated total pyramidal neuron numbers ...
Inhibition of neuronal nitric oxide synthase prevents iron-induced cerebellar Purkinje cell loss in the rat
(Nencki Inst Experimental Biology, 2008)
Iron plays an important role in maintaining normal. brain function. However, in many neurodegenerative diseases abnormal iron accumulation in specific brain regions has been consistently reported. In this study, we ...
The Effect of Neuronal Nitric Oxide Synthase Inhibitor 7-Nitroindazole on the Cell Death Induced by Zinc Administration in the Brain of Rats
(Tubitak Scientific & Technical Research Council Turkey, 2009)
Aim: To evaluate the effect of the neuronal nitric oxide synthase (nNOS) inhibitor 7-nitroindazole (7-Nl) on hippocampal cell loss induced by zinc hemisulfate salt (ZnSO4-7H2O) treatment. Materials and Methods: Rats were ...
Iron-Induced Cerebellar Purkinje Cell Loss Is Ameliorated by Flunarizine
(Tubitak Scientific & Technical Research Council Turkey, 2009)
Aim: In this study, we investigated the effect of intracerebroventricular-injected iron neurotoxicity on the total number of cerebellar Purkiinje cells in rats and the possible neuroprotective effect of flunarizine, a ...
Neuroprotective effect of aminoguanidine on iron-induced neurotoxicity
(Pergamon-Elsevier Science Ltd, 2008)
Iron is a commonly used metal to induce neuronal hyperactivity and oxidative stress. Iron levels rise in the brain in some neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. A body of evidence indicates ...
Nitric oxide synthesis inhibition attenuates iron-induced neurotoxicity: A stereological study
(Elsevier Science Bv, 2008)
Iron overload and enhanced hydroxyl radical formation have been implicated as the causative factors of some neurodegenerative disorders. Therefore, iron is commonly used as a metal to induce neuronal hyperactivity and ...
Role of nitric oxide synthesis inhibitors in iron-induced nigral neurotoxicity: A mechanistic exploration
(Taylor & Francis Ltd, 2008)
In the central nervous system, nitric oxide (NO) has been suggested to be a cell-to-cell signaling molecule that regulates guanylyl cyclase, aconitase, and iron regulatory protein. NO is also one of the substances that is ...
Neuroprotection by 7-nitroindazole against iron-induced hippocampal neurotoxicity
(Springer/Plenum Publishers, 2007)
(1) Iron plays an important role in maintaining normal brain function. In some neurodegenerative disorders including Parkinson's and Alzheimer's disease, iron levels rise in the brain. It is known that higher iron levels ...