Browsing by Author "Yigit, Serbulent"
Now showing items 1-20 of 22
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Association between fibromyalgia syndrome and polymorphism of the IL-4 gene in a Turkish population
Yigit, Serbulent; Inanir, Ahmet; Tekcan, Akin; Inanir, Sema; Tural, Sengul; Ates, Omer (Elsevier Science Bv, 2013)Purpose: Fibromyalgia (FM) syndrome is a form of non-articular rheumatism characterized by long term and widespread musculoskeletal pain, morning stiffness, sleep disturbance, paresthesia, and pressure hyperalgesia at ... -
Association between sequence variations of the Mediterranean fever gene and fibromyalgia syndrome in a cohort of Turkish patients
Karakus, Nevin; Yigit, Serbulent; Inanir, Ahmet; Inanir, Sema; Toprak, Huriye; Okan, Sevil (Elsevier, 2012)Objective: Fibromyalgia syndrome (FMS) is a common chronic widespread pain syndrome mainly affecting women. Genetic risk factors are known to contribute to the etiology of the syndrome. Clinical features show that FMS and ... -
Association between the methylene tetrahydrofolate reductase gene C677T mutation and colchicine unresponsiveness in Behcet's disease
Karakus, Nevin; Yigit, Serbulent; Kalkan, Goknur; Rustemoglu, Aydin; Inanir, Ahmet; Gul, Ulker; Ates, Omer (Molecular Vision, 2012)Purpose: Behcet's disease (BD) is a multisystemic immunoinflammatory disorder characterized by mucocutaneous, ocular, vascular, and central nervous system manifestations. The common methylene tetrahydrofolate reductase ... -
Association of angiotensin converting enzyme (ACE) gene I/D polymorphism and rheumatoid arthritis
Yigit, Serbulent; Inanir, Ahmet; Tural, Sengul; Ates, Omer (Elsevier, 2012)We sought to determine the frequency of I/D polymorphism genotypes of angiotensin converting enzyme gene in Turkish patients with rheumatoid arthritis. Genomic DNA obtained from 256 individuals (110 patients with rheumatoid ... -
Association of IL-4 gene VNTR variant with deep venous thrombosis in Behcet's disease and its effect on ocular involvement
Inanir, Ahmet; Tural, Sengul; Yigit, Serbulent; Kalkan, Goknur; Pancar, Gunseli Sefika; Demir, Helin Deniz; Ates, Omer (Molecular Vision, 2013)Purpose: Behcet's disease (BD) is a systemic vasculitis characterized by inflammatory lesions of the urogenital mucosa, eyes, skin, central nervous system, and joints. Vein thrombosis constitutes the most frequent vascular ... -
Association of MEFV Gene Mutations With Rheumatoid Factor Levels in Patients With Rheumatoid Arthritis
Inanir, Ahmet; Yigit, Serbulent; Karakus, Nevin; Tekin, Saban; Rustemoglu, Aydin (Bmj Publishing Group, 2013)Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease primarily affecting the joints. Arthritis disorders are associated with mutations of the Mediterranean fever (MEFV) gene. This gene has already been ... -
C Deletion in Exon 4 Codon 63 of p53 Gene in Turkish Patients with Oral Squamous Cell Carcinoma
Tekcan, Akin; Gumusay, Ozge; Nursal, Ayse Feyda; Yigit, Serbulent; Yildiz, Serkan; Tumer, Mehmet Kemal (Kare Publ, 2020)OBJECTIVE Oral squamous cell carcinoma (OSCC) is the most frequently seen oral malignancy and accounts for up to 80-90% of all malignant neoplasms that occurin the oral cavity. The p53 tumor suppressor gene plays a crucial ... -
Clinical significance of MEFV mutations in ankylosing spondylitis
Durmus, Dilek; Alayli, Gamze; Cengiz, Kivanc; Yigit, Serbulent; Canturk, Ferhan; Bagci, Hasan (Elsevier France-Editions Scientifiques Medicales Elsevier, 2009)Objective: The aim of the present study was to investigate the prevalence of MEFV gene mutations in patients with ankylosing spondylitis (AS) and to assess the clinical significance of the MEFV gene mutations in AS. Methods: ... -
Common Mediterranean fever (MEFV) gene mutations associated with ankylosing spondylitis in Turkish population
Yigit, Serbulent; Inanir, Ahmet; Karakus, Nevin; Kesici, Esra; Bozkurt, Nihan (Hindawi Ltd, 2012)Ankylosing spondylitis (AS) is a common inflammatory rheumatic disease. Mediterranean fever (MEFV) gene, which has already been identified as being responsible for familial Mediterranean fever (FMF), is also a suspicious ... -
DD genotype of ACE gene I/D polymorphism is associated with Behcet disease in a Turkish population
Yigit, Serbulent; Tural, Sengul; Rustemoglu, Aydin; Inanir, Ahmet; Gul, Ulker; Kalkan, Goknur; Ates, Omer (Springer, 2013)Behcet's disease (BD) is a chronic, multi-systemic and inflammatory disorder. The local renin-angiotensin system (RAS) in the vessel wall plays a role in the endothelial control and contributes to inflammatory processes. ... -
IL-4 and MTHFR gene polymorphism in rheumatoid arthritis and their effects
Inanir, Ahmet; Yigit, Serbulent; Tekcan, Akin; Tural, Sengul; Kismali, Gorkem (Elsevier, 2013)Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease that mainly affects the joints. Polymorphic variations of the cytokine genes and MTHFR gene have received attention as potential markers of susceptibility, ... -
Influence of PON1 gene polymorphisms (rs662 and rs854560) on the chronicity of HBV infection
Karakus, Nevin; Duygu, Fazilet; Coskun, Umut Say; Atay, Ayfer; Yigit, Serbulent (Elsevier, 2020)Hepatitis B is a major health problem in Turkey as it is all over the world. Therefore, it is noteworthy to understand the genetic background of hepatitis B virus (HBV)-infection. In order to investigate the effect of the ... -
Investigation of Associations between Obesity and LEP G2548A and LEPR 668A/G Polymorphisms in a Turkish Population
Sahin, Server; Rustemoglu, Aydin; Tekcan, Akin; Tasliyurt, Turker; Guven, Hasan; Yigit, Serbulent (Hindawi Publishing Corporation, 2013)Objective. Obesity is a complex heterogeneous disease that is caused by genes, environmental factors, and the interaction between the two. The leptin (LEP) and leptin receptor (LEPR) genes have been evaluated for polymorphisms ... -
The Investigation of Obesity Susceptibility with IL-4 Gene Intron 3 VNTR and IL-6 Gene-597G/A Polymorphisms in a Turkish Population
Tekcan, Akin; Yigit, Serbulent; Rustemoglu, Aydin; Gurel, Cevik; Sahin, Server; Tasliyurt, Turker (Kamla-Raj Enterprises, 2013)Obesity results in a proinflammatory state starting within the metabolic cells as adipocyte, monocyte. The bioactive system, including cytokines as IL-4 and IL-6, contributes to the pathogenesis of conditions associated ... -
Macrophage Migration Inhibitory Factor-173GC Variant Might Increase the Risk of Behcet's Disease
Nursal, Ayse Feyda; Yigit, Serbulent; Tural, Ercan; Kalkan, Goknur; Tumer, Mehmet Kemal; Tekcan, Akin (Karger, 2018)Objective: The aim of the present study was to investigate any possible association between the macrophage migration inhibitory factor (MIF) -173GC variant and Behcet's disease (BD) in a group of Turkish patients. Subjects ... -
MEFV mutations in patients with familial Mediterranean fever in the Black Sea region of Turkey
Yigit, Serbulent; Bagci, Hasan; Ozkaya, Ozan; Ozdamar, Kazim; Cengiz, Kuddusi; Akpolat, Tekin (J Rheumatol Publ Co, 2008)Objective. To investigate MEFV mutations among patients with familial Mediterranean fever (IMF), their relatives, and healthy controls in the Black Sea region of Turkey; to compare 3 different MEFV mutation analysis methods; ... -
Molecular Analysis of Genetic Variation in Angiotensin I-Converting Enzyme Gene in Turkish Athletes
Inanir, Ahmet; Cenikli, Abdullah; Tural, Ercan; Tekcan, Akin; Tural, Sengul; Cakil, Duygu; Yigit, Serbulent (Kamla-Raj Enterprises, 2014)Genetic factors play an important role in physical performance. The angiotensin converting enzyme (ACE) gene polymorphism is the most studied genetic marker in the field of human performance. The aim of this study was to ... -
MTHFR gene C677T mutation and ACE gene I/D polymorphism in Turkish patients with osteoarthritis
Inanir, Ahmet; Yigit, Serbulent; Tural, Sengul; Cecen, Osman; Yildirim, Eren (Hindawi Ltd, 2013)Osteoarthritis is a degenerative joint disorder resulting in destruction of articular cartilage, osteophyte formation, and subchondral bone sclerosis. In recent years, numerous genetic factors have been identified and ... -
The role of IL-4 gene 70 bp VNTR and ACE gene I/D variants in Familial Mediterranean fever
Yigit, Serbulent; Tural, Sengul; Tekcan, Akin; Tasliyurt, Turker; Inanir, Ahmet; Uzunkaya, Suheyla; Kismali, Gorkem (Academic Press Ltd- Elsevier Science Ltd, 2014)Familial Mediterranean fever (FMF) is characterized by recurrent attacks of fever and inflammation in the peritoneum, synovium, or pleura, accompanied by pain. It is an autosomal recessive disease caused by mutations in ... -
Significance of MEFV gene R202Q polymorphism in Turkish familial Mediterranean fever patients
Yigit, Serbulent; Karakus, Nevin; Tasliyurt, Turker; Kaya, Suheyla Uzun; Bozkurt, Nihan; Kisacik, Bunyamin (Elsevier Science Bv, 2012)Objective: Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by recurrent attacks of fever and inflammation in the peritoneum, synovium, or pleura, accompanied by pain. The disease is ...
