Browsing by Author "Tural, Sengul"
Now showing items 1-20 of 24
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Association between fibromyalgia syndrome and polymorphism of the IL-4 gene in a Turkish population
Yigit, Serbulent; Inanir, Ahmet; Tekcan, Akin; Inanir, Sema; Tural, Sengul; Ates, Omer (Elsevier Science Bv, 2013)Purpose: Fibromyalgia (FM) syndrome is a form of non-articular rheumatism characterized by long term and widespread musculoskeletal pain, morning stiffness, sleep disturbance, paresthesia, and pressure hyperalgesia at ... -
Association between osteoporosis and polymorphisms of the bone Gla protein, estrogen receptor 1, collagen 1-A1 and calcitonin receptor genes in Turkish postmenopausal women
Tural, Sengul; Kara, Nurten; Alayli, Gamze; Tomak, Leman (Elsevier Science Bv, 2013)In this study, we have investigated the association between osteoporosis and osteocalcin (BGLAP) -298 C>T, estrogen receptor 1 (ER1) 397 T>C, collagen type1 alpha 1 (Col1A1) 2046 G>T and calcitonin receptor (CALCR) 1340 ... -
Association between osteoporosis and polymorphisms of the IL-10 and TGF-beta genes in Turkish postmenopausal women
Tural, Sengul; Alayli, Gamze; Kara, Nurten; Tander, Berna; Bilgici, Ayhan; Kuru, Omer (Elsevier Science Inc, 2013)Osteoporosis is a multifactorial disease in which genetic determinants are modulated by hormonal, environmental and nutritional factors. The balance between bone resorption and bone formation seems to be regulated by a ... -
Association of angiotensin converting enzyme (ACE) gene I/D polymorphism and rheumatoid arthritis
Yigit, Serbulent; Inanir, Ahmet; Tural, Sengul; Ates, Omer (Elsevier, 2012)We sought to determine the frequency of I/D polymorphism genotypes of angiotensin converting enzyme gene in Turkish patients with rheumatoid arthritis. Genomic DNA obtained from 256 individuals (110 patients with rheumatoid ... -
Association of IL-4 gene VNTR variant with deep venous thrombosis in Behcet's disease and its effect on ocular involvement
Inanir, Ahmet; Tural, Sengul; Yigit, Serbulent; Kalkan, Goknur; Pancar, Gunseli Sefika; Demir, Helin Deniz; Ates, Omer (Molecular Vision, 2013)Purpose: Behcet's disease (BD) is a systemic vasculitis characterized by inflammatory lesions of the urogenital mucosa, eyes, skin, central nervous system, and joints. Vein thrombosis constitutes the most frequent vascular ... -
A Case with Partial 9p Trisomy and Speech Impairment
Elbistan, Mehrnet; Tekcan, Akin; Tural, Sengul; Karakus, Nevin; Kara, Nurten (Derman Medical Publ, 2015)In this study, we aimed to discuss the relationships between his phenotypic anomalies and der(15), ish t(9; 15)(p12; q10) balanced reciprocal translocation entity that determined from 5 year old male child who referred to ... -
Chromosomal microarray analysis of patients with Duane retraction syndrome
Niyaz, Leyla; Tural, Sengul; Yucel, Ozlem Eski; Can, Ertugrul; Ariturk, Nursen; Celik, Zulfinaz B.; Kara, Nurten (Springer, 2019)Purpose Duane retraction syndrome (DS) is a rare congenital strabismus with genetic heterogeneity. The genetic causes of DS are not always of monogenic origin; various chromosomal copy number variations (CNVs) have also ... -
The combined QF-PCR and cytogenetic approach in prenatal diagnosis
Tekcan, Akin; Tural, Sengul; Elbistan, Mehmet; Kara, Nurten; Guven, Davut; Kocak, Idris (Springer, 2014)In this study, the importance of quantitative fluorescence polymerase chain reaction (QF-PCR) aneuploidy diagnosis test which provides earlier and easier results were discussed. The cell cultures and DNA isolations were ... -
Cytogenetic Findings of Patients with Amenorrhea in Turkish Population: A Retrospective Study
Kara, Nurten; Tural, Sengul; Elbistan, Mehmet; Karakus, Nevin; Guven, Davut; Kocak, Idris (Kamla-Raj Enterprises, 2012)We performed a retrospective study, with the purpose of establishing the frequency of chromosomal anomalies in amenorrhea cases referred to our genetic laboratory from hospitals in the Middle Black Sea of Turkey. In this ... -
DD genotype of ACE gene I/D polymorphism is associated with Behcet disease in a Turkish population
Yigit, Serbulent; Tural, Sengul; Rustemoglu, Aydin; Inanir, Ahmet; Gul, Ulker; Kalkan, Goknur; Ates, Omer (Springer, 2013)Behcet's disease (BD) is a chronic, multi-systemic and inflammatory disorder. The local renin-angiotensin system (RAS) in the vessel wall plays a role in the endothelial control and contributes to inflammatory processes. ... -
Effects of FSHR Gene Variants on Ovarian Response
Gulhan, Cayci; Ozdemir, Ayse Z.; Onal, Mesut; Tural, Sengul; Guven, Davut; Kocak, Idris (Kamla-Raj Enterprises, 2020)The study aimed to evaluate the effects of Follicle Stimulating Hormone Receptor (FSHR) gene rs747317735 and rs6111 variants on ovarian response. The researchers evaluated 57 cases (27of them were poor ovarian responders, ... -
Effects of leptin and leptin receptor gene polymorphisms on lung cancer
Unsal, Meftun; Kara, Nurten; Karakus, Nevin; Tural, Sengul; Elbistan, Mehmet (Springer, 2014)Leptin (LEP), an adipocyte-derived cytokine, has been reported to participate in carcinogenesis. Elevated levels of systemic and pulmonary LEP are associated with diseases related to lung injury and lung cancer. The purpose ... -
Effects of subtelomeric copy number variations in miscarriages
Tekcan, Akin; Elbistan, Mehmet; Tural, Sengul; Cetinkaya, Mehmet Bilge (Taylor & Francis Ltd, 2015)Purpose: This study was performed on miscarriage samples for chromosome analysis to detect copy number variations (CNVs) related to subtelomeric regions, and with these results we aimed to adapt multiplex ligation-dependent ... -
Evaluation of apoptotic cell death on liver and kidney tissues following administration of levetiracetam during prenatal period
Tekcan, Akin; Tural, Sengul; Elbistan, Mehmet; Guvenc, Tolga; Ayas, Bulent; Kara, Nurten (Taylor & Francis Ltd, 2017)Objective: Levetiracetam is a new generation antiepileptic drug used in treatment of patients with epilepsy and has adverse effects on different tissues. We aimed to evaluate the apoptotic effects of levetiracetam exposure ... -
Evaluation of CYP17A1 and LEP Gene Polymorphisms in Breast Cancer
Karakus, Nevin; Kara, Nurten; Ulusoy, Ali N.; Ozaslan, Cihangir; Tural, Sengul; Okan, Ismail (Karger, 2015)Background: Polymorphisms of estrogen synthesis- and adiposity-related genes can contribute to the development of breast cancer. The purpose of the current study was to analyze the association between CYP17A1 T27C (rs743572) ... -
FMR1 gene mutation screening by TP-PCR in patients with premature ovarian failure and fragile-X
Tural, Sengul; Tekcan, Akin; Kara, Nurten; Elbistan, Mehmet; Guven, Davut; Tasdemir, Haydar Ali (Informa Healthcare, 2015)CGG repeat expansion in the FMR1 gene is associated with fragile X syndrome, fragile X-associated tremor/ ataxia syndrome and fragile X-associated primary ovarian insufficiency. In this study, FMR1 gene mutation screening ... -
Genotoxic Effects of Prenatal Exposure to Levetiracetam During Pregnancy on Rat Offsprings
Tural, Sengul; Tekcan, Akin; Elbistan, Mehmet; Karakus, Nevin; Ozyurek, Hamit; Kara, Nurten (Int Inst Anticancer Research, 2015)Levetiracetam is a new-generation antiepileptic drug initially approved as an adjunctive treatment for patients with refractory partial seizures and is now also used as a monotherapy. The aim of this study was to evaluate ... -
IL-4 and MTHFR gene polymorphism in rheumatoid arthritis and their effects
Inanir, Ahmet; Yigit, Serbulent; Tekcan, Akin; Tural, Sengul; Kismali, Gorkem (Elsevier, 2013)Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease that mainly affects the joints. Polymorphic variations of the cytokine genes and MTHFR gene have received attention as potential markers of susceptibility, ... -
Molecular Analysis of Genetic Variation in Angiotensin I-Converting Enzyme Gene in Turkish Athletes
Inanir, Ahmet; Cenikli, Abdullah; Tural, Ercan; Tekcan, Akin; Tural, Sengul; Cakil, Duygu; Yigit, Serbulent (Kamla-Raj Enterprises, 2014)Genetic factors play an important role in physical performance. The angiotensin converting enzyme (ACE) gene polymorphism is the most studied genetic marker in the field of human performance. The aim of this study was to ... -
MTHFR gene C677T mutation and ACE gene I/D polymorphism in Turkish patients with osteoarthritis
Inanir, Ahmet; Yigit, Serbulent; Tural, Sengul; Cecen, Osman; Yildirim, Eren (Hindawi Ltd, 2013)Osteoarthritis is a degenerative joint disorder resulting in destruction of articular cartilage, osteophyte formation, and subchondral bone sclerosis. In recent years, numerous genetic factors have been identified and ...
